Resume

1984.9-1988.6, Bachelor of Chemistry, Department of Chemistry, Central China Normal University, P. R. China.

1988.9-1991.6, Postgraduate of Chemistry, Institute of Pesticidal Chemistry, Central China Normal University, P.R. China.

1999.9-2002.6, Doctoro f Chemistry, College of Chemistry,Central China Normal University, P. R. China.

1993.9-1996.10, Lecture, Institute of Pesticide Chemistry,Central China Normal University, P. R. China.

1996.10-2002.9, Associate Professor, Institute of Pesticide Chemistry, Central China Normal University, P. R. China.

2002.10--, Professor Dr., College of Chemistry, Central China Normal University, P. R. China.

2004—Doctor tutor, Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, P. R. China

Research Fields and Interests

Our research interestis focused on Herterocyclic Chemistry, Organophophosphorus Chemistry and Pesticidal Chemistry, especially onnew synthetic method for biologically active heterocycliccompounds. The main research content is as follows:

1. Synthesis of potentially biological active herterocyclic compounds via aza-Wittig reaction or catalytic aza-Wittig reactions.We have developed several efficient synthetic methods for various heterocyclesand fused heterocycles. These heterocycles include 4H-imidazol-4-ones,4(3H)-quinazolinonoes, thieno[2,3-d]pyrimidin-4(3H)-ones, oxazoles,benzimidazoles, thiazoles, pyrimidines, imidazoles, etc. Further synthesis ofother new heterocyclic system by using I-MCR/aza-Wittig sequence is still onprogress.

2. Design and synthesis of new heterocycles with potential fungicidal activities. The fungicidal activities of triazole compounds with sterol inhibitory activity, imidazole compounds with mitochondrial respiratory inhibitory activity and new lead compounds with potent inhibitive activity on Scytalone Dehydratase ofrice blast fungi are investigated and some of lead compounds are found. The relationship between biological activities and structure of the heterocycle is also our interest.

Selected Publications

1. Yan,Y. M.; Rao, Y.; Ding, M. W.* One-Pot Synthesis of Multisubstituted Benzimidazoles via Sequential Ugi and Catalytic aza-Wittig Reaction Starting from 2-Aminobenzoyl Azides. J. Org. Chem. 2016, 81, 1263-1268.

2. Wang,L.; Guan, Z. R.; Ding, M. W.* One-PotSynthesis of 1H-Isochromenes and 1,2-Dihydroisoquinolines by a Sequential Isocyanide-based Multicomponent/Wittig Reaction. Org. Biomol. Chem. 2016, 14, 2413-2420.

3. Zeng,X. H.; Wang, H. M.; Ding, M. W.* Unexpected Synthesis of 5,6-Dihydropyridin-2(1H)-ones by a Domino Ugi/Aldol/ Hydrolysis Reaction Starting from Baylis-Hillman Phosphonium Salts. Org. Lett. 2015, 17, 2234-2237.

4. Wang,L.; Ren, Z. L.; Ding, M. W.* Synthesisof 2,3-Dihydro-1H-2-benzazepin-1-ones and 3H-2-Benzoxepin-1-onesby Isocyanide-based Multicomponent Reaction/Wittig Sequence Starting from Phosphonium Salt Precursors. J. Org. Chem. 2015, 80, 641-646.

5. Wang,L.; Wang, Y.; Chen, M.; Ding, M. W.* Reversible P^III/P^VRedox: Catalytic Aza-Wittig Reaction for Synthesis of 4(3H)-Quinazolinones and Natural Product Vasicinone. Adv. Synth. Catal.2014,356, 1098-1104.

6. Yuan,D.; Duan, Z.; Rao, Y.; Ding, M. W.* New Efficient Synthesis of Isoquinoline-1,3(2H,4H)-diones and Isoindolin-1-onesvia Sequential Ugi/Cyclization Reaction. Tetrahedron 2016, 72, 338-346.

7. Yan, Y. M.; Gao, Y.; Ding, M. W.* NewEfficient Synthesis of Multisubstituted Benzimidazoles and Quinoxalin-2(1H)-onesby a Ugi 4CC/aza-Wittig Sequence Starting from Aromatic Amine Precursors.T etrahedron 2016, 72, 5548-5557.

8. Xie,H.; Yuan, D.; Ding, M. W.* Unexpected Synthesis of 2,4,5-Trisubstituted Oxazoles via a Tandem aza-Wittig/Michael/Isomerization Reaction of Vinyliminophosphorane. J. Org. Chem. 2012, 77, 2954-2958.

9. Nie,Y. B.; Wang, L.; Ding, M. W.* Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles by a Sequentialaza-Wittig/Michael/Isomerization Reaction. J. Org. Chem. 2012, 77, 696-700.

10. Xie, H.; Liu, J. C.; Wu, L.; Ding,M. W.* New Efficient Synthesis of Trisubstituted 1H-Imidazole-2(3H)-thiones and Thiazoles via Vinyliminophosphoranes. Tetrahedron 2012, 68, 7984-7990.

Honors and Awards

1. Ding, M. W.; Huang, W. F.;Liu, Z. J.; Wu, T. J.Studies on the (aza-)Wittig Reaction and Synthesis of Novel Heterocycles. The Natural Science Prize ofHubei Province in 2000.

2. Yang, G. F.; He, H. W.; Wan, J.; Xiao, W. J.;Ding, M. W. Strategy of Molecular Design and Synthetic Methods of Novel Pesticides. The Natural Science Prize of Hubei Province in 2005.

3. Yang, G. F.; Zhan, C. G.; Wan, J.; Ding, M. W.;Zhang, L. Basic Studies on Development of Novel Pesticides. The Natural Science Prize of Ministry of Education in 2006.

4. Ding, M. W.;Liu, M. G.; Huang, N. Y.; Xu, S. Z.; He, P. Development of newsynthetic method for heterocyclic compounds via iminophosphorane. The Natural Science Prize of Hubei Province in 2014.