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个人信息

姓名：林红艳

学历：博士研究生

职称：副教授

E-mail：hylin@mail.ccnu.edu.cn

教育与研究经历

研究领域与兴趣

长期从事农药化学生物学及农药靶标结构生物学研究。解析了100多个不同种属对羟苯基丙酮酸双加氧酶（HPPD）与小分子（底物、中间体、产物、抑制剂、天然产物等）的复合物晶体结构，结合AlphaFold2技术构建了迄今最完善的HPPD三维结构数据库，为基于结构和酶催化反应机理的HPPD抑制剂设计奠定了坚实的理论基础。此外，还系统揭示了团队自主创制的新型除草剂喹草酮和吡唑喹草酯的作用机制。先后主持了国家自然科学基金、湖北省自然科学基金、湖北省重点研发计划等多个科研项目，以第一作者或通讯作者身份先后在JACS、JAFC、FEBS J、Structure、Trends Biochem Sci、CCL、Research等国际知名期刊发表SCI论文10多篇。荣获科创中国·湖北科技经济融合优秀项目一等奖 (2023，排名第4)。

主要学术兼职： Journal of Agricultural and Food Chemistry青年编委、Advanced Agrochem青年编委。

承担项目与课题信息

1. 主持国家自然科学基金面上项目（22377031），执行期20240101-20271231，50万元。

2. 主持国家自然科学基金青年项目（22007035），执行期20210101-20231231，24万元。

3. 主持湖北省自然科学基金青年项目（2020CFB487），执行期20200301-20220301，5万元。

4. 主持湖北省揭榜制科技项目（2022BEC051），执行期20230101-20251231，50万元。

5. 主持武汉市知识创新专项（2022013301015174），执行期20221001-20240930，20万元。

6. 主持中央高校基本科研业务费（KJ02502022-0622），执行期20220901-20230901，10万元。

7. 主持中央高校基本科研业务费（KJ02072020-0657），执行期20200401-20201231，5万元。

学术成果（代表性论文）

【1】 Jin Dong,^† Han Xiao,^† Jia-Nan Chen, Bai-Feng Zheng, Yu-Ling Xu, Meng-Xi Chen, Wen-Chao Yang, Hong-Yan Lin,* and Guang-Fu Yang. Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors. Structure 2023, doi.org/10.1016/j.str.2023.09. 005.

【2】 Hong-Yan Lin,^† Jin Dong,^† Jiangqing Dong,^† Wen-Chao Yang, and Guang-Fu Yang.* Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology. Trends Biochem Sci. 2023, 48, 568-584.

【3】 Jin Dong,^† Jiangqing Dong,^† Xin-He Yu, Yao-Chao Yan, Jia-Xu Nan, Bao-Qin Ye, Wen-Chao Yang, Hong-Yan Lin,^* and Guang-Fu Yang.^* Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design. J Agric Food Chem 2023, 71, 1170-1177.

【4】 Jin Dong,^† Jiangqing Dong,^† Xin-He Yu, Yao-Chao Yan, Jia-Xu Nan, Bo He, Bao-Qin Ye, Wen-Chao Yang, Hong-Yan Lin,^* and Guang-Fu Yang.^* Structural Insights of 4-Hydrophenylpyruvate Dioxygenase Inhibition by Structurally Diverse Small Molecules. Advanced Agrochem 2022, 1, 174-181.

【5】 Yao-Chao Yan, Wei Wu, Guang-Yi Huang, Wen-Chao Yang, Qiong Chen, Ren-Yu Qu,^* Hong-Yan Lin,^* and Guang-Fu Yang. Pharmacophore-Oriented Discovery of Novel 1, 2, 3-Benzotriazine-4-one Derivatives as Potent 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. J Agric Food Chem 2022, 70, 6644-6657.

【6】 Hong-Yan Lin,^† Xi Chen,^† Jin Dong,^† Jing-Fang Yang, Han Xiao, Ying Ye, Lin-Hui Li, Chang-Guo Zhan, Wen-Chao Yang,^* and Guang-Fu Yang.^* Rational Redesign of Enzyme via the Combination of Quantum Mechanics/Molecular Mechanics, Molecular Dynamics, and Structural Biology Study. J Am Chem Soc 2021, 143, 15674−15687.

【7】 Ren-Yu Qu, Jia-Xu Nan, Yao-Chao Yan, Qiong Chen, Ferdinand Ndikuryayo, Xue-Fang Wei, Wen-Chao Yang, Hong-Yan Lin,^* Guang-Fu Yang.^* Structure-Guided Discovery of Silicon-Containing Subnanomolar Inhibitor of Hydroxyphenylpyruvate Dioxygenase as a Potential Herbicide. J Agric Food Chem 2021, 69, 459-473.

【8】 Bo He, Feng-Xu Wu, Liang-Kun Yu, Lei Wu, Qiong Chen, Ge-Fei Hao, Wen-Chao Yang, Hong-Yan Lin,^* Guang-Fu Yang.^* Discovery of Novel Pyrazole−Quinazoline-2,4-dione Hybrids as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. J Agric Food Chem 2020, 68, 5059-5067.

【9】 Hong-Yan Lin,^† Jiang-Fang Yang,^† Da-Wei Wang, Ge-Fei Hao, Jiang-Qing Dong, Yu-Xia Wang, Wen-Chao Yang,^* Jia-Wei Wu, Chang-Guo Zhan, Guang-Fu Yang.^* Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations. FEBS J 2019, 286, 975-990.

【10】 Hong-Yan Lin,^† Xi Chen,^† Jia-Nan Chen, Da-Wei Wang, Feng-Xu Wu, Song-Yun Lin, Chang-Guo Zhan, Jia-Wei Wu, Wen-Chao Yang,^* Guang-Fu Yang.^* Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals a New Starting Point for Herbicide Discovery. Research 2019, 2019, 2602414.